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American Journal of Clinical Nutrition, Vol 23, 913-918, Copyright © 1970 by The American Society for Clinical Nutrition, Inc.

Relationship of Serum Tocopherol to Beta-Lipoprotein Concentrations in Liver Diseases

R. M. H. KATER M.B., M.R.A.C.P.1, W. J. UNTERECKER A.B.1, C. Y. KIM M.D.1, and C. S. DAVIDSON M.D.1

1 From the Thorndike Memorial Laboratory, Harvard Medical Unit, Boston City Hospital, Boston, Massachusetts

Patients with severe cirrhosis and fulminant hepatitis had significantly decreased serum tocopherol concentrations compared with healthy and hospitalized controls. No correlation was found between serum tocopherol concentration and adequacy of the dietary intake of tocopherol preceding the illness. A direct correlation was found between concentrations of tocopherol and beta-lipoprotein in serum. We suggest that in severe liver disease a critical degree of malfunction may be reached when beta-lipoprotein production is impaired sufficiently to cause a decrease in serum tocopherol.






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Copyright © 1970 by The American Society for Nutrition