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American Journal of Clinical Nutrition, Vol 23, 940-947, Copyright © 1970 by The American Society for Clinical Nutrition, Inc.

Studies of Bladder Stone Disease in Thailand

XII. The Effect of Methionine and Pyridoxine Supplements on Urinary Sulfate

ROBERT VAN REEN PH.D.1, AREE VALYASEVI M.D.1, and SAKORN DHANAMITTA M.D.1

1 From the SEATO Clinical Research Center (CRC), Bangkok, Thailand, and the Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland

Eighteen infants, 5-18 months of age, living in an endemic bladder stone area of Ubol Province, Thailand, were administered dl-methionine, pyridoxine·HCl, or placebo in a cross-over, multiple Latinsquare designed study. Following 6 days of treatment, 24-hr urine samples were collected and analyzed for various components. Inorganic sulfate excretion was increased following methionine administration, but not with pyridoxine. These data, plus those indicating low urea excretion by village children compared with Bangkok subjects, suggest that protein malnutrition exists in Ubol villages and may contribute to the etiology of bladder stone disease.






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