AJCN Tufts Nutrition Symposium, Boston Sept 24-26
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American Journal of Clinical Nutrition, Vol 23, 1005-1008, Copyright © 1970 by The American Society for Clinical Nutrition, Inc.

Comments on the Mechanisms of Disordered Divalent Ion Metabolism in Renal Failure

A Possible Role of Magnesium Depletion

SHAUL G. MASSRY M.D.1 and JACK W. COBURN M.D.1

1 From the Departments of Medicine, Cedars-Sinai Medical Center, Veterans Administration Center, and the University of California School of Medicine, Los Angeles, California

In the course of progressive chronic renal disease, a resistance to both the action of vitamin D and the effect of parathyroid hormone on bone develops and is largely responsible for the occurrence of hypocalcemia. It is proposed that magnesium depletion may exist in patients with renal insufficiency and play an important role in the pathogenesis of these abnormalities.







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Copyright © 1970 by The American Society for Nutrition