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American Journal of Clinical Nutrition, Vol 23, 1012-1014, Copyright © 1970 by The American Society for Clinical Nutrition, Inc.

Pituitary Adrenal Axis Evaluation in Human Scurvy

ABBAS E. KITABCHI PH.D., M.D.1 and WILLIAM C. DUCKWORTH M.D.1

1 From the Laboratories of Endocrinology and Metabolism, Research Service, Veterans Administration Hospital, and the Departments of Biochemistry and Medicine, The University of Tennessee Medical Units, Memphis, Tennessee

The pituitary-adrenal axis was investigated in two patients with biochemical and clinical evidence of scurvy before and after treatment with ascorbic acid. Baseline plasma cortisol and the plasma and urinary steroid responses to ACTH and metyrapone were unchanged by treatment with ascorbic acid. No evidence of adrenal hypofunction was found.






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Copyright © 1970 by The American Society for Nutrition