AJCN 19th International Congress of Nutrition
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American Journal of Clinical Nutrition, Vol 23, 1229-1233, Copyright © 1970 by The American Society for Clinical Nutrition, Inc.

Hypocholesterolemic Effect of 4,4'-(Isopropylidenedithio)-Bis(2,6-di-t-Butylphenol) (Probucol)

JAMES W. BARNHART PH.D.1, JOAN A. SEFRANKA B.S.1, and DAVID D. MCINTOSH A.B.1

1 From Human Health Research and Development Laboratories, the Dow Chemical Company, Zionsville, Indiana 46077

Probucol (DH-581) is a lipophilic bisphenol that lowers serum cholesterol in several species. There is no effect on liver weight or liver cholesterol, and there is no consistent effect on serum and liver triglycerides. Incorporation of mevalonate-2-14C into cholesterol is not affected, indicating that probucol does not exert an influence on the late stages of biosynthesis. An inhibition of lipoprotein formation or transport is suggested.




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