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American Journal of Clinical Nutrition, Vol 24, 117-123, Copyright © 1971 by The American Society for Clinical Nutrition, Inc.

Comparison of ileal and jejunal biopsies in tropical sprue

Munsey S. Wheby M.D.1, Virginia L. Swanson M.D.1, and Theodore M. Bayless M.D.1

1 From the U.S. Army Tropical Research Medical Laboratory and The University of Puerto Rico School of Medicine, San Juan, Puerto Rico

Jejunal and ileal biopsies were compared histologically and by dissecting microscopy in 27 patients with tropical sprue. Fifteen of the patients were previously untreated, whereas 12 were treated with either tetracycline or folic acid or vitamin B12, or both. By dissecting microscopy the jejunum was judged to be more abnormal than the ileum in 15 of 27 patients. However, by histologic criteria, the mucosal abnormalities in 20 of the 27 pairs of biopsies were considered to be of equal severity. We conclude that in tropical sprue the ileum and jejunum are usually equally affected by the injurious process.






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Copyright © 1971 by The American Society for Nutrition