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American Journal of Clinical Nutrition, Vol 24, 848-851, Copyright © 1971 by The American Society for Clinical Nutrition, Inc.

A possible role of urinary metabolites of tryptophan in the heterotopic recurrence of bladder cancer in man

Osamu Yoshida M.D.1, Raymond R. Brown Ph.D.1, and George T. Bryan M.D., Ph.D.1

1 From The Division of Clinical Oncology, University of Wisconsin Medical School, Madison, Wisconsin 53706

The following conclusions appear justified. Relative to clinical studies on tryptophan metabolism in patients with bladder tumors, considerable evidence has been accumulated to support the tryptophan metabolite-bladder cancer hypothesis; no evidence has been shown to refute this hypothesis. As there is the relationship between tryptophan metabolism and heterotopic recurrences of human bladder cancer, clinical trials should be made to further substantiate this and to ascertain if vitamin B6 administration might retard the development of these recurrences.






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Copyright © 1971 by The American Society for Nutrition