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American Journal of Clinical Nutrition, Vol 25, 125-130, Copyright © 1972 by The American Society for Clinical Nutrition, Inc.

Vitamin interchange between ascitic fluid and blood in man

Michael F. Sorrell M.D.1, Oscar Frank Ph.D.1, Hermes Aquino M.D.1, Allan D. Thomson M.D.1, Maceo M. Howard M.D.1, and Herman Baker Ph.D.1

1 From the Division of Hepatic Metabolism and Nutrition, Departments of Medicine and Preventive Medicine, College of Medicine and Dentistry of New Jersey, 88 Ross Street, East Orange, New Jersey 07018, and the East Orange Veterans Administration Hospital, East Orange, New Jersey, 07019

All the water-soluble vitamins, together with vitamins A and E, were administered to 12 patients with ascites; 3 ingested the vitamins; 3 received vitamins by an intravenous route; and 6 received vitamins directly into the ascitic fluid by intraperitoneal administration. Ascitic fluid contains significant amounts of all vitamins; folate, and ascorbate concentrations are almost in equilibrium with blood. Folate, B12, pantothenate, thiamin, biotin, ascorbate, and riboflavin can interchange between ascitic fluid and circulating fluid; vitamins A and E cannot interchange, even though levels are elevated in these respective fluids after loading. Pantothenate and B6 can pass from ascitic fluid to blood, but cannot pass from blood to ascitic fluid. Ascitic fluid can store exogenous vitamins for a longer period than blood and is capable of filtering exogenous vitamins from the blood.







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Copyright © 1972 by The American Society for Nutrition