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American Journal of Clinical Nutrition, Vol 25, 135-139, Copyright © 1972 by The American Society for Clinical Nutrition, Inc.

Comparison of blood clearance of ethanol and tolbutamide and the activity of hepatic ethanol-oxidizing and drug-metabolizing enzymes in chronic alcoholic subjects

Madhukar N. Shah M.D.1, Barbara A. Clancy M.A.1, and Frank L. Iber M.D.1

1 From the Division of Gastroenterology and Department of Medicine, Lemuel Shattuck Hospital and Tufts University School of Medicine, Boston, Massachusetts 02130

After 1 year of heavy drinking, six alcoholic men were hospitalized for 10 weeks of abstinence and studied serially. The removal rate of alcohol and tolbutamide from the blood, the in vivo activity of two liver microsomal enzymes, and alcohol dehydrogenase were determined three times in each subject. When compared, the rates of alcohol and tolbutamide removal were higher on admission than 10 weeks later. Liver alcohol dehydrogenase increased with time, whereas the activity of the two microsomal liver enzymes decreased with time. Thus the drinking alcoholic has both increased drug metabolism and increased drug-metabolizing enzymes and both decrease with time of abstinence. No correlation was found between the removal rate of alcohol in the whole body and alcohol dehydrogenase levels in the liver.






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Copyright © 1972 by The American Society for Nutrition