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American Journal of Clinical Nutrition, Vol 25, 147-151, Copyright © 1972 by The American Society for Clinical Nutrition, Inc.

Folate requirements of children. I. A formula diet low in folic acid for study of folate deficiency in protein-calorie malnutrition

Carol I. Waslien Ph.D.1, Karim Kamel M.D., Ph.D., M.R.C. Path.1, Zeinab El-Ramly M.B., D.Ch.1, James P. Carter M.D.1, Khalil A. Mourad M.B., M.R.C.P.1, Abdel-Khalek Khattab M.D., Ph.D., F.R.C.P.1, and William J. Darby M.D., Ph.D.1

1 From the United States Naval Medical Research Unit No. 3 (NAMRU-3) % Spanish Embassy, Cairo; the Department of Pediatrics, Ain Shams University Faculty of Medicine, Cairo, Egypt; and Division of Nutrition, Vanderbilt University, Nashville, Tennessee

A formula low in folate and of known and constant composition has been developed and evaluated in the treatment of children with protein-calorie malnutrition. The course of recovery, as judged by disappearance of clinical edema, weight gain, regeneration of serum albumin, and observed clinical improvement, was compared with that of a similar group of children receiving a whole milk formula. The results were comparable in both groups. The specific effects on hemopoiesis of administering to children fed this formula diet graded quantities of folic acid is described in the accompanying paper (1).

The use of such a diet in clinical investigations can introduce a much needed degree of comparability and control of experimental studies of nutritional anemias in early childhood.




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