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American Journal of Clinical Nutrition, Vol 25, 175-181, Copyright © 1972 by The American Society for Clinical Nutrition, Inc.

Regression of alcoholic fatty liver in the rat by medium-chain triglycerides

Richard C. Theuer Ph.D.1, Wilbur H. Martin 1, Timothy J. Friday M.S.1, Barry L. Zoumas Ph.D.1, and Herbert P. Sarett Ph.D.1

1 From the Department of Nutritional Research, Mead Johnson Research Center, Evansville, Indiana 47721

Previous studies have shown that rats fed alcohol diets containing medium-chain triglycerides (MCT) accumulate less liver fat than rats fed similar diets containing long-chain triglycerides (LCT). The present findings indicate that feeding MCT diets to rats with alcohol-induced fatty livers improves the rate of regression of the lesions. Fatty livers were produced in rats by feeding a liquid diet in which corn oil and alcohol each supplied 35% of calories. After 5 weeks, the rats were fed similar diets in which sucrose replaced alcohol, or MCT replaced corn oil, or both substitutions were made. Chemical and histological regression of liver lesions was most rapid when the diet contained both MCT and sucrose. In comparing the effects of single substitution of MCT or sucrose in the corn oil-alcohol diet, chemical regression was more rapid when sucrose replaced alcohol, whereas histological regression occurred faster when MCT replaced corn oil. The difference between MCT and LCT in the development and regression of hepatic steatosis attributed to prolonged alcohol ingestion is probably due to the differing digestive, absorptive, and metabolic properties of these fats.




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E. A. Porta
Dietary Modulation of Oxidative Stress in Alcoholic Liver Disease in Rats
J. Nutr., May 1, 1997; 127 (5): 912S - 912S.
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