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American Journal of Clinical Nutrition, Vol 25, 365-367, Copyright © 1972 by The American Society for Clinical Nutrition, Inc.

Changes in skin surface lipid composition induced by severe caloric restriction in man

Donald T. Downing Ph.D.1, John S. Strauss M.D.1, and Peter E. Pochi M.D.1

1 From the Departments of Dermatology and Biochemistry, Boston University School of Medicine and the Evans Memorial Department of Clinical Research, University Hospital, Boston University Medical Center, Boston, Massachusetts 02118

After 5 days without food, human subjects showed a marked change in sebaceous gland composition of the forehead skin lipid, apparently as the result of suppression of the synthesis of all lipids except squalene in the sebaceous glands. The change was reversed by return to a normal diet.




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