AJCN EB Program 2010 Early Registration
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sanchez, A.
Right arrow Articles by Register, U. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sanchez, A.
Right arrow Articles by Register, U. D.
Agricola
Right arrow Articles by Sanchez, A.
Right arrow Articles by Register, U. D.

American Journal of Clinical Nutrition, Vol 26, 1180-1184, Copyright © 1973 by The American Society for Clinical Nutrition, Inc.

Role of sugars in human neutrophilic phagocytosis

Albert Sanchez 1, J. L. Reeser 1, H. S. Lau 1, P. Y. Yahiku 1, R. E. Willard 1, P. J. McMillan 1, S. Y. Cho 1, A. R. Magie 1, and U. D. Register 1

1 From the Departments of Nutrition, Biostatistics, and Environmental Health in the School of Health, and the Department of Microbiology, Pathology, and Anatomy in the School of Medicine, Loma Linda University, Loma Linda, California 92354

This study was designed to test a) whether carbohydrates other than glucose decreased the phagocytic capacity of neutrophils in normal human subjects, b) the duration of this effect, and c) the effect of fasting on neutrophilic phagocytosis. Venous blood was drawn from the arm after an overnight fast and at 0.5, 1, 2, 3, or 5 hr postprandial and this was incubated with a suspension of Staphylococcus epidermidis. The phagocytic index (mean number of bacteria viewed within each neutrophil) was determined by microscopic examination of slides prepared with Wright's stain. Oral 100-g portions of carbohydrate from glucose, fructose, sucrose, honey, or orange juice all significantly decreased the capacity of neutrophils to engulf bacteria as measured by the slide technique. Starch ingestion did not have this effect. The decrease in phagocytic index was rapid following the ingestion of simple carbohydrates. The greatest effects occurred between 1 and 2 hr postprandial, but the values were still significantly below the fasting control values 5 hr after feeding (P < 0.001). The decreased phagocytic index was not significantly associated with the number of neutrophils. These data suggest that the function and not the number of phagocytes was altered by ingestion of sugars. This implicates glucose and other simple carbohydrates in the control of phagocytosis and shows that the effects last for at least 5 hr. On the other hand, a fast of 36 or 60 hr significantly increased (P < 0.001) the phagocytic index.




This article has been cited by other articles:


Home page
 Integr Cancer TherHome page
C. A. Krone and J. T. A. Ely
Controlling Hyperglycemia as an Adjunct to Cancer Therapy
Integr Cancer Ther, March 1, 2005; 4(1): 25 - 31.
[Abstract] [PDF]

Home page
 Exp. Biol. Med.Home page
J. T.A. Ely and C. A. Krone
Aging: Predictions of a New Perspective on Old Data
Experimental Biology and Medicine, December 1, 2002; 227(11): 939 - 942.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1973 by The American Society for Nutrition