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American Journal of Clinical Nutrition, Vol 26, 1311-1319, Copyright © 1973 by The American Society for Clinical Nutrition, Inc.

Food iron absorption in man. II. Isotopic exchange of iron between labeled foods and between a food and an iron salt

Erik Björn-Rasmussen 1, Leif Hallberg 1, and Richard B. Walker 1

1 From the Department of Medicine II, University of Göteborg, Sahlgrenska sjukhuset, Göteborg, Sweden, and the Department of Botany, University of Washington, Seattle, Washington

The new extrinsic tag method to measure food iron absorption is based on an extrinsic labeling of the dietary heme and non-heme iron. The main prerequisite for this method is that a rapid and complete isotopic exchange takes place within a pool of non-heme iron. The purpose of the present study was to test the validity of this concept in further detail. In one series, the absorption from a biologically radioiron-labeled food (soybeans, wheat, or rice) was equal to the absorption of an inorganic radioiron tracer added during preparation of the food. This was true in spite of a marked difference in specific radioactivity between the two tracers. Moreover, when following the plasma radioactivity after a meal prepared from a biologically labeled food (soybeans or wheat) and an added inorganic radioiron tracer, identical plasma activity curves were found. In another series in which two different radioiron isotopes were biologically incorporated into two foods (eggs and wheat) served together, the two tracers were equally absorbed. The results of the three series are all consistent with the concept of a complete isotopic exchange within a pool of non-heme iron. The present as well as earlier results support the conclusion that the extrinsic tag method can be validly used to measure the absorption of dietary non-heme iron.




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