American Journal of Clinical Nutrition, Vol 26, 259-263, Copyright © 1973 by The American Society for Clinical Nutrition, Inc.

Nutrition, metabolism, and blood lipids in humans with type II_A hyperlipoproteinemia

¹ From the Mayo Clinic and Mayo Foundation, Rochester, Minnesota 55901

Increasing the polyunsaturated fat and decreasing the saturated fat in the diet did not affect plasma cholesterol levels in 18 patients with type II_A hyperlipoproteinemia. Increasing dietary cholesterol increased plasma cholesterol levels. Increasing dietary carbohydrate increased plasma triglyceride levels but not beyond the normal range. Quantities of carbohydrate, protein, and fat used for basal and exercise metabolism were not changed despite considerable changes in fat and carbohydrate contents of diets. Under conditions of carbohydrate stress, lipoprotein profiles characteristic of type III or type IV hyperlipoproteinemia were not observed. Traces or small amounts of pre- HDL were present in all but 2 of the 18 patients, and traces of pre- VLDL were present in 14 patients.