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American Journal of Clinical Nutrition, Vol 26, 487-490, Copyright © 1973 by The American Society for Clinical Nutrition, Inc.

Ammonia content of food

Daniel Rudman M.D.1, Robert B. Smith III M.D.1, Atef A. Salam M.D.1, W. Dean Warren M.D.1, John T. Galambos M.D.1, and Julius Wenger M.D.1

1 From the Departments of Medicine, Biochemistry, and Surgery, Emory University School of Medicine, and the Clinical Research Facility, Emory University Hospital, Atlanta, Georgia 30322

Sixty-four foods were analyzed for ammonia (NH3) content. In 16 foods, NH3 constituted 3 to 23% of total nitrogen; in 22 foods, the proportion was 1 to 3%; in 26, the proportion was less than 1%.

The smallest quantity of dietary NH3 in the form of ammonium chloride required to increase blood NH3 concentration over 150 µg/100 ml was measured in 32 cirrhotic patients with a history of encephalopathy. This quantity was 0.04 g NH3 or less per 50 kg body wt in eight subjects.

One serving of eight of the foods studied contains 0.04 g NH3 or more. The data thus indicate that ingestion of preformed NH3 in certain foods contributes to hyperammonemia in cirrhotic patients.




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