American Journal of Clinical Nutrition, Vol 27, 1110-1116, Copyright © 1974 by The American Society for Clinical Nutrition, Inc.

Comparison of alpha-tocopheryl nicotinate and acetate on skin microcirculation

¹ From the Sapporo Medical School, Sapporo, Japan

Clinical observations were made on persons with microcirculatory disturbances after administration of -tocopheryl nicotinate. It was observed that the clinical symptoms of severe acrocyanosis and "feeling cold" were cured. All subjects were given the cooling-rewarming test. The experimental results indicated the tocopheryl nicotinate had strong effects on the microcirculation of the hand. The data show that -tocopheryl nicotinate was more effective than the -tocopheryl acetate and a mixture of -tocopheryl acetate and nicotinic acid in reducing the mean rewarming time and that the effectiveness of -tocopheryl nicotinate was not due to the synergic action of the tocopherol and nicotinic acid, but to the independent action of -tocopheryl nicotinate.