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American Journal of Clinical Nutrition, Vol 27, 1174-1178, Copyright © 1974 by The American Society for Clinical Nutrition, Inc.

A double-blind trial of vitamin E in angina pectoris

Terence W. Anderson B.M., B.Ch., Ph.D.1 and D. B. William Reid M.Sc.1

1 From the Department of Epidemiology and Biometrics, School of Hygiene, University of Toronto, Toronto, Ontario, Canada

The claim that large doses of vitamin E can relieve the symptoms of angina pectoris has been strenuously debated for over 20 years. The few clinical trials that were carried out (around 1950) gave negative results, but these trials have been criticized on the grounds of small numbers, poor design, or inadequate dosage. The present trial was therefore carried out on 50 patients, using a randomized double-blind design, and a daily dosage of 3,200 IU of vitamin E or placebo. The results were not conclusive.




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