AJCN Tufts Nutrition Symposium, Boston Sept 24-26
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takeuchi, A.
Right arrow Articles by Robinson, D. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takeuchi, A.
Right arrow Articles by Robinson, D. M.
Agricola
Right arrow Articles by Takeuchi, A.
Right arrow Articles by Robinson, D. M.

American Journal of Clinical Nutrition, Vol 27, 1287-1296, Copyright © 1974 by The American Society for Clinical Nutrition, Inc.

Spiral-shaped organisms on the surface colonic epithelium of the monkey and man

Akio Takeuchi M.D.1, Helen R. Jervis D.Sc.1, Hiroshi Nakazawa M.D.1, and David M. Robinson M.D.1

1 From Department of Experimental Pathology, Division of Pathology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D.C. 20012; Laboratories, Nyack Hospital, Nyack, N. Y.: Department of Pathology, Walter Reed General Hospital, Walter Reed Army Medical Center

Intestinal spirochetosis is the infestation of the gut mucosa by spiral-shaped organisms. Intestinal spirochetosis was studied in healthy rhesus monkeys (Macaca mulatta) and human subjects by histology, histochemistry, transmission and scanning electron microscopy. The incidence of intestinal spirochetosis is 28% in monkeys and 2% in human subjects. Intestinal spirochetosis is not associated with any gastrointestinal symptoms. In both primates, the morphologic characteristics and the relationship to the host are indistinguishable. Spiral organisms stained with H & E appear as broad basophilic haze on the colonic surface and are strongly positive by Warthin-Starry (silver) stain. Spiral-shaped organisms include two structurally different organisms, spirochetes and flagellated microbes. They intimately populate the brush border region of the surface of the colonic epithelium. They are absent in the crypt and in the small intestine. Infestation by spirochetes produces no alterations of cytocomponents of the underlying host structures. Under as yet undetermined conditions, spirochetes are capable of penetrating beyond the brush border region into the epithelial cytoplasm and also into the lamina propria. Although this occurrence is very rare, it is possible for mucosal penetration, when it occurs in large numbers to cause structural alteration and clinical symptoms in hosts.




This article has been cited by other articles:


Home page
 J Med MicrobiolHome page
E. Corona-Barrera, D. G.E. Smith, T. La, D. J. Hampson, and J. R. Thomson
Immunomagnetic separation of the intestinal spirochaetes Brachyspira pilosicoli and Brachyspira hyodysenteriae from porcine faeces
J. Med. Microbiol., April 1, 2004; 53(4): 301 - 307.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
M. A. Munshi, N. M. Taylor, A. S. J. Mikosza, P. B. S. Spencer, and D. J. Hampson
Detection by PCR and Isolation Assays of the Anaerobic Intestinal Spirochete Brachyspira aalborgi from the Feces of Captive Nonhuman Primates
J. Clin. Microbiol., March 1, 2003; 41(3): 1187 - 1191.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
N. Trivett-Moore, G. Gilbert, C. Law, D. Trott, and D. Hampson
Isolation of Serpulina pilosicoli from rectal biopsy specimens showing evidence of intestinal spirochetosis [In Process Citation]
J. Clin. Microbiol., January 1, 1998; 36(1): 261 - 265.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1974 by The American Society for Nutrition