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American Journal of Clinical Nutrition, Vol 27, 584-589, Copyright © 1974 by The American Society for Clinical Nutrition, Inc.

Studies in calcium metabolism. I. The calciuretic effect of dietary protein

S. Margen M.D.1, J.-Y. Chu M.D., Ph.D.2, N. A. Kaufmann M.D.3, and D. H. Calloway Ph.D.4

1 Professor of Human Nutrition, Department of Nutritional Sciences, University of California, Berkeley, California 94720
2 Resident, Department of Pediatrics, Kings County Hospital Center, 451 Clarkson Avenue, Brooklyn, New York 11203
3 Senior Lecturer, Mayer de Rothschild Hadassah University Hospital, 17 Hechaluz Street, P.O. Box 499, Jerusalem, Israel
4 Professor of Nutrition, Department of Nutritional Sciences, University of California

Data are presented from several studies concerning the effect of varying protein intake on urinary calcium excretion, A markedly positive correlation was found between protein ingestion and calciuria. Although the response was not linear, varying protein intake from 0 g to 90 g N per day results in approximately an 800% increase in calcium excretion, irrespective of calcium intake. This effect of protein occurred in all our studies of individuals, and was also observed with pure l-amino acid mixtures.




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