AJCN Tufts Nutrition Symposium, Boston Sept 24-26
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American Journal of Clinical Nutrition, Vol 27, 629-637, Copyright © 1974 by The American Society for Clinical Nutrition, Inc.

Bactericidal activities of phagocytes in health and disease

Anthony J. Sbarra 1, Ratnam J. Selvaraj 1, Benoy B. Paul 1, R. R. Strauss 1, A. Alice Jacobs 1, and George W. Mitchell Jr. 1

1 From the Department of Pathology and Medical Research, St. Margaret's Hospital, and the Department of Obstetrics and Gynecology, Tufts University School of Medicine, Boston, Massachusetts 02125

It is clear from the above that all questions regarding host defense mechanisms cannot be answered now. What is clear, however, is that a beginning has been made. For example, phagocytes in leukocytes from children with PCM do not appear to engulf or kill bacteria as well as leukocytes collected from control children. Importantly, these deficient leukocytes have altered biochemical activities that serve to explain the inability of normal uptake and bactericidal activities. Data such as this, although more difficult to obtain, may prove more informative than uptake studies only. Such data, however, may pave the way for furthering our understanding of the role of phagocytosis in health and disease.






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Copyright © 1974 by The American Society for Nutrition