AJCN Tufts Nutrition Symposium, Boston Sept 24-26
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American Journal of Clinical Nutrition, Vol 27, 676-680, Copyright © 1974 by The American Society for Clinical Nutrition, Inc.

Absorption and passage of fat- and water-soluble thiamin derivatives into erythrocytes and cerebrospinal fluid of man

Herman Baker Ph.D.1, Allan D. Thomson M.D.1, Oscar Frank Ph.D.1, and Carroll M. Leevy M.D.1

1 From the Division of Liver and Nutrition, Departments of Medicine and Preventive Medicine, College of Medicine and Dentistry of New Jersey-New Jersey Medical School, 88 Ross Street, East Orange, New Jersey 07018, and Martland Hospital Unit, Newark, New Jersey 07013

Oral administration of the lipid-soluble allithiamins, thiamin propyl disulfide and thiamin tetrahydrofurfuryl disulfide, caused a significant increase in thiamin activity in whole blood, red blood cells, and cerebrospinal fluid equivalent to that produced by parenteral, water-soluble thiamin hydrochloride and thiamin pyrophosphate. In contrast, oral administration of the water-soluble thiamins did not significantly elevate thiamin activity in biological fluids; this was probably due to their rate-limited intestinal transport. The odor of thiamin propyl disulfide limits its usefulness in multivitamins and food fortification. Thiamin tetrahydrofurfuryl disulfide is odorless and is therefore more useful for such purposes. Orally administered allithiamin vitamers are recommended for prophylaxis and treatment of thiamin deficits because they have the same biological properties as parenterally administered water-soluble thiamins.






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Copyright © 1974 by The American Society for Nutrition