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American Journal of Clinical Nutrition, Vol 27, 774-776, Copyright © 1974 by The American Society for Clinical Nutrition, Inc.

Vitamin E supplements and the absorption of a massive dose of vitamin A

Jane A. Kusin 1, Vinodini Reddy 1, and B. Sivakumar 1

1 From the National Institute of Nutrition, Indian Council of Medical Research, Jamai-Osmania, Hyderabad-500007, India

The effect of vitamin E supplements on the absorption of a massive dose of vitamin A was studied in 17 normal children. They were divided into four groups. Each child was given 4 to 5 µCi of (11, 12-3 H2) retinyl acetate along with 200,000 IU of cold vitamin A. Group I received only vitamin A, whereas groups II, III, and IV received in addition to vitamin A, 40, 100, and 500 mg dl-alpha tocopherol acetate, respectively. The addition of 40 and 100 mg of vitamin E to the massive dose of vitamin A had no effect on the absorption or retention of vitamin A. When 500 mg of vitamin E was given, there was a significant increase in the intestinal absorption of vitamin A and also an increase in the urinary excretion. There was no significant difference in the retention of vitamin A in these children as compared with those who received vitamin A without vitamin E.




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