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American Journal of Clinical Nutrition, Vol 27, 1017-1025, Copyright © 1974 by The American Society for Clinical Nutrition, Inc.

Age, parity, and vitamin A supplementation and the vitamin E requirement of female rats

Stanley R. Ames Ph.D.1

1 From the Biochemistry Research Laboratory, Health and Nutrition Research Division, Research Laboratories, Tennessee Eastman Company, Division of Eastman Kodak Company, Rochester, New York 14603

The objective was to determine the amount of d-agr-tocopheryl acetate needed for successful reproduction in rats at various ages, of different parities, and at several levels of vtiamin A supplementation. The median fertility dose was determined by using the resorption-gestation bioassay of Mason and Harris. Neither the number of previous pregnancies nor level of vitamin A supplementation (80, 4,000, and 20,000 IU/l00 g of diet) had a significant effect on the vitamin E requirement. The vitamin E requirement increased markedly with age. The vitamin E requirement for rats 9 to 11 weeks old was set as the standard. The requirement for rats 43 to 45 weeks old was 11 times the standard, and that for rats 59 weeks old was 67 times the standard. The vitamin E requirement for prevention of erythrocyte hemolysis (a measure of absorption) in rats 71 to 72 weeks old was three times that for rats 9 to 11 weeks old. Therefore, the large increases in the vitamin E requirement of rats of increasing age were not due to decreased absorption in the older rats. It is concluded that the vitamin E requirement for reproduction in the rat increases markedly with an increase in age but is not affected by different parities or by vitamin A supplementation.




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[Abstract] [Full Text] [PDF]


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Copyright © 1974 by The American Society for Nutrition