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American Journal of Clinical Nutrition, Vol 27, 980-986, Copyright © 1974 by The American Society for Clinical Nutrition, Inc.
1 From the Section on Nutritional Biochemistry, Laboratory of Nutrition and Endocrinology, National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014
Studies with labeled compounds showed that 
-tocopherol was absorbed from the intestine of rats about as efficiently as 
-tocopherol but that -tocopherol disappeared faster from tissues after 24 hr. When these tocopherols were fed continuously in the diet as they occur naturally in corn and soybean oils, -tocopherol accumulated significantly in tissues to varying degrees. Adipose tissue had the highest concentration, heart, kidney, and muscle were intermediate and plasma and liver were lowest. Reevaluation of the relative biological activity of -tocopherol in rats, chicks, and hamsters gave an overall value of 10% that of -tocopherol. Changing dietary fat patterns in the United States have resulted in soybean oil becoming the predominant dietary fat (70% of all vegetable fat), with the result that average diets have twice as much -tocopherol as -tocopherol. These factors indicate that -tocopherol may contribute as much as 20% of the total vitamin E activity of United States diets, and that calculations based only on -tocopherol significantly underestimate dietary vitamin E.
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