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American Journal of Clinical Nutrition, Vol 28, 831-836, Copyright © 1975 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Zinc deficiency occurring in females. Report of two cases

HA Ronaghy and JA Halsted

The syndrome of dwarfism, hypogonadism, iron-deficiency anemia and geophagia, first reported in 1960 from Iran, was thought to be limited to males. In 1971-1972 two females with the same clinical features were observed over a 14-month period. The anemia responded rapidly to iron. Growth and sexual development occurred promptly when 120 mg of zinc sulfate was administered daily in conjunction with a well-balanced diet and iron supplement. This diet prior to the addition of zinc sulfate, resulted in gradual but much slower growth and sexual development. Observations in these two patients provide confirmation of the occurrence of human zinc deficiency in females, which responds to large doses of zinc salt.


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I.M.W. Ebisch, C.M.G. Thomas, W.H.M. Peters, D.D.M. Braat, and R.P.M. Steegers-Theunissen
The importance of folate, zinc and antioxidants in the pathogenesis and prevention of subfertility
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Copyright © 1975 by The American Society for Nutrition