AJCN EB Program 2010 Early Registration
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pirola, R. C.
Right arrow Articles by Lieber, C. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pirola, R. C.
Right arrow Articles by Lieber, C. S.
Agricola
Right arrow Articles by Pirola, R. C.
Right arrow Articles by Lieber, C. S.

American Journal of Clinical Nutrition, Vol 29, 90-93, Copyright © 1976 by The American Society for Clinical Nutrition, Inc

REVIEW ARTICLES

Hypothesis: energy wastage in alcoholism and drug abuse: possible role of hepatic microsomal enzymes

RC Pirola and CS Lieber

Hepatic microsomal drug oxidation appears to be an energy-wasteful process because it has no known link with energy-conserving mechanisms such as the synthesis of ATP, and in addition it requires the uncoupled oxidation of NADPH. It is postulated that this can appreciably alter the energy balance of the whole body under certain conditions. Such an imbalance would be favored by the repeated intake of drugs that induce hepatic microsomal enzymes and by the provision of ethanol as a major source of calories. The hypothesis is consistent with the changes in body weight in humans and animals after chronic ethanol intake. It is supported by observations of an increased oxygen consumption in rats given ethanol or barbiturates in doses that induce hepatic microsomal enzymes.


This article has been cited by other articles:


Home page
 Alcohol AlcoholHome page
I. BYKOV, M. PALMEN, L. PIIRAINEN, and K. O. LINDROS
ORAL CHRONIC ETHANOL ADMINISTRATION TO RODENTS BY AGAR GEL DIET
Alcohol Alcohol., November 1, 2004; 39(6): 499 - 502.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S. Q Siler, R. A Neese, and M. K Hellerstein
De novo lipogenesis, lipid kinetics, and whole-body lipid balances in humans after acute alcohol consumption
Am. J. Clinical Nutrition, November 1, 1999; 70(5): 928 - 936.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
E. Jequier
Alcohol intake and body weight: a paradox
Am. J. Clinical Nutrition, February 1, 1999; 69(2): 173 - 174.
[Full Text] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
L. Marsano and C. J. Mcclain
Review: Nutrition and Alcoholic Liver Disease
JPEN J Parenter Enteral Nutr, May 1, 1991; 15(3): 337 - 344.
[Abstract] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
W. J. John, R. Phillips, L. Ott, L. J. Adams, and C. J. Mcclain
Resting Energy Expenditure in Patients with Alcoholic Hepatitis
JPEN J Parenter Enteral Nutr, March 1, 1989; 13(2): 124 - 127.
[Abstract] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
C. Mendenhall, G. Bongiovanni, S. Goldberg, B. Miller, J. Moore, S. Rouster, D. Schneider, C. Tamburro, T. Tosch, R. Weesner, et al.
VA Cooperative Study on Alcoholic Hepatitis III: Changes in Protein-Calorie Malnutrition Associated with 30 Days of Hospitalization with and without Enteral Nutritional Therapy
JPEN J Parenter Enteral Nutr, September 1, 1985; 9(5): 590 - 596.
[Abstract] [PDF]

Home page
 ANN INTERN MEDHome page
C. R. FLEMING and J. A. HIGGINS
Alcohol: Nutrient and Poison
Ann Intern Med, October 1, 1977; 87(4): 492 - 493.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1976 by The American Society for Nutrition