American Journal of Clinical Nutrition, Vol 3, 141-147, Copyright © 1955 by The American Society for Clinical Nutrition, Inc.

Effect of a Therapeutic Regime on Hyperchylomicronemia and Hypercholesterolemia

¹ From the Heart Disease Control Unit, Mississippi State Board of Health

Lipotropic substances—choline, methionine, and inositol in a balanced formula (Methischol)—were administered to 11 patients with proved past myocardial infarction for not less than nine weeks and to 24 elderly women for nine weeks, and to 12 for twelve weeks, the latter group having no history of myocardial infarction.

After nine or more weeks of administration of the lipotropic mixture to the myocardial infarction group, there was a decrease of borderline statistical significance in the total serum cholesterol levels. No such variation was observed in the control group even after prolonged therapy; neither was there any appreciable variation following the administration of a lactose placebo in capsules of identical appearance.

There was a statistically highly significant depression of chylomicron levels (per cent of microscopically visible lipoprotein particles 0.3 micron in diameter and larger) in all subjects on the above regime. Intermittent discontinuation and repeated administration of these substances in four atherosclerotic subjects, followed from five to twelve months, resulted alternately in elevation and depression of chylomicron levels, respectively. Placebo administration did not result in a change in chylomicron levels beyond the statistically expected and experimentally confirmed variation.

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