| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 30, 531-538, Copyright © 1977 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
KN Jeejeebhoy, RC Chu, EB Marliss, GR Greenberg and A Bruce-Robertson
A white female, now age 40 and receiving total parenteral nutrition for more than 5 years, developed unexpected 15% weight loss after 3 1/2 years of regimen, together with peripheral neuropathy confirmed by nerve conduction measurements. An intravenous glucose tolerance test showed that the fractional rate (K) had decreased to 0.89%/min (normal greater than 1.2). There was observed during this glucose infusion a borderline normal insulin response with a fall in plasma free fatty acids and in plasma leucine. During daily infusion of well over 400 g of glucose, the respiratory quotient was 0.66. Chromium balance was negative. Chromium levels were, in blood 0.55 ng/ml (normal 4.9 to 9.5) and in hair 154 to 175 ng/g (normal greater than 500). Regular insulin daily (45 micron) in the infusate nearly maintained euglycemia but despite this, and even with further glucose intake to restore weight loss, intravenous glucose tolerance test (K) and respiratory quotient were unchanged. Administration of insulin was then stopped and 250 microng of Cr added to the daily total parenteral nutrition infusate for 2 weeks. After this the intravenous glucose tolerance test (K) and respiratory quotient became normal (1.35 and 0.78, respectively). Over the next 5 months insulin was not needed and glucose intake had to be reduced substantially to avoid overweight. In this period nerve conduction and well-being returned to normal. With a maintenance addition of chromium to the total parenteral nutrition infusate (tentatively this addition is 20 microng/day) the patient has remained well for 18 months (to July 1976). These results suggest that relatively isolated chromium deficiency in man, hitherto poorly documented, causes 1) glucose intolerance, 2) inability to utilize glucose for energy, 3) neuropathy with normal insulin levels, 4) high free fatty acid levels and low respiratory quotient and, 5) abnormalities of nitrogen metabolism.
This article has been cited by other articles:
|
|
 |
|
  M. V. Potenza and J. I. Mechanick The Metabolic Syndrome: Definition, Global Impact, and Pathophysiology Nutr Clin Pract, October 1, 2009; 24(5): 560 - 577. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Nahas and M. Moher Complementary and alternative medicine for the treatment of type 2 diabetes Can Fam Physician, June 1, 2009; 55(6): 591 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Dong, M. R. Kandadi, J. Ren, and N. Sreejayan Chromium (D-phenylalanine)3 Supplementation Alters Glucose Disposal, Insulin Signaling, and Glucose Transporter-4 Membrane Translocation in Insulin-Resistant Mice J. Nutr., October 1, 2008; 138(10): 1846 - 1851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Via, C. Scurlock, J. Raikhelkar, G. D. Luozzo, and J. I. Mechanick Chromium Infusion Reverses Extreme Insulin Resistance in a Cardiothoracic ICU Patient Nutr Clin Pract, June 1, 2008; 23(3): 325 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Howard, C. Ashley, D. Lyon, and A. Shenkin Autopsy Tissue Trace Elements in 8 Long-Term Parenteral Nutrition Patients Who Received the Current U.S. Food and Drug Administration Formulation JPEN J Parenter Enteral Nutr, September 1, 2007; 31(5): 388 - 396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Balk, A. Tatsioni, A. H. Lichtenstein, J. Lau, and A. G. Pittas Effect of Chromium Supplementation on Glucose Metabolism and Lipids: A systematic review of randomized controlled trials Diabetes Care, August 1, 2007; 30(8): 2154 - 2163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Fuhrman Micronutrient Assessment in Long-Term Home Parenteral Nutrition Patients Nutr Clin Pract, December 1, 2006; 21(6): 566 - 575. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Rink, S. Roy, S. Khanna, T. Rink, D. Bagchi, and C. K. Sen Transcriptome of the subcutaneous adipose tissue in response to oral supplementation of type 2 Leprdb obese diabetic mice with niacin-bound chromium Physiol Genomics, November 21, 2006; 27(3): 370 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Shenkin Micronutrients in health and disease. Postgrad. Med. J., September 1, 2006; 82(971): 559 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Wani, C. Weskamp, J. Marple, and L. Spry Acute Tubular Necrosis Associated with Chromium Picolinate-Containing Dietary Supplement Ann. Pharmacother., March 1, 2006; 40(3): 563 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Aghdassi, I. E. Salit, L. Fung, L. Sreetharan, S. Walmsley, and J. P. Allard Is Chromium an Important Element in HIV-Positive Patients with Metabolic Abnormalities? An Hypothesis Generating Pilot Study. J. Am. Coll. Nutr., February 1, 2006; 25(1): 56 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Q. Wang, X. H. Zhang, J. C. Russell, M. Hulver, and W. T. Cefalu Chromium Picolinate Enhances Skeletal Muscle Cellular Insulin Signaling In Vivo in Obese, Insulin-Resistant JCR:LA-cp Rats J. Nutr., February 1, 2006; 136(2): 415 - 420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Gunton, N. W. Cheung, R. Hitchman, G. Hams, C. O'Sullivan, K. Foster-Powell, and A. McElduff Chromium Supplementation Does Not Improve Glucose Tolerance, Insulin Sensitivity, or Lipid Profile: A randomized, placebo-controlled, double-blind trial of supplementation in subjects with impaired glucose tolerance Diabetes Care, March 1, 2005; 28(3): 712 - 713. [Full Text] [PDF]
|
|
|
|
|
|
W. T. Cefalu and F. B. Hu Role of Chromium in Human Health and in Diabetes Diabetes Care, November 1, 2004; 27(11): 2741 - 2751. [Full Text] [PDF]
|
|
|
|
 |
|
 M. D Althuis, N. E Jordan, E. A Ludington, and J. T Wittes Glucose and insulin responses to dietary chromium supplements: a meta-analysis Am. J. Clinical Nutrition, July 1, 2002; 76(1): 148 - 155. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. T. Cefalu, Z. Q. Wang, X. H. Zhang, L. C. Baldor, and J. C. Russell Oral Chromium Picolinate Improves Carbohydrate and Lipid Metabolism and Enhances Skeletal Muscle Glut-4 Translocation in Obese, Hyperinsulinemic (JCR-LA Corpulent) Rats J. Nutr., June 1, 2002; 132(6): 1107 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Crone, G. Gabriel, and T. N. Wise Non-Herbal Nutritional Supplements--The Next Wave: A Comprehensive Review of Risks and Benefits for the C-L Psychiatrist Psychosomatics, August 1, 2001; 42(4): 285 - 299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E Gunton, G. Hams, R. Hitchman, and A. McElduff Serum chromium does not predict glucose tolerance in late pregnancy Am. J. Clinical Nutrition, January 1, 2001; 73(1): 99 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Misra and D. F. Kirby Invited Review: Micronutrient and Trace Element Monitoring in Adult Nutrition Support Nutr Clin Pract, June 1, 2000; 15(3): 120 - 126. [Abstract] [PDF]
|
|
|
|
|
|
R. A. Anderson Chromium, Glucose Intolerance and Diabetes J. Am. Coll. Nutr., December 1, 1998; 17(6): 548 - 555. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Moore, M. A. Maher, W. J. Banz, and M. B. Zemel Chromium Picolinate Modulates Rat Vascular Smooth Muscle Cell Intracellular Calcium Metabolism J. Nutr., February 1, 1998; 128(2): 180 - 184. [Abstract] [Full Text]
|
|
|
|
|
|
A. H. Verhage, W. K. Cheong, and K. N. Jeejeebhoy Neurologic Symptoms Due to Possible Chromium Deficiency in Long-Term Parenteral Nutrition That Closely Mimic Metronidazole-Induced Syndromes JPEN J Parenter Enteral Nutr, March 1, 1996; 20(2): 123 - 127. [Abstract] [PDF]
|
|
|
|
|
|
T. G. Baumgartner Invited Review: Trace Elements in Clinical Nutrition Nutr Clin Pract, December 1, 1993; 8(6): 251 - 263. [Abstract] [PDF]
|
|
|
|
|
|
K. Sando, M. Hoki, R. Nezu, Y. Takagi, and A. Okada Platelet Glutathione Peroxidase Activity in Long-Term Total Parenteral Nutrition With and Without Selenium Supplementation JPEN J Parenter Enteral Nutr, January 1, 1992; 16(1): 54 - 58. [Abstract] [PDF]
|
|
|
|
 |
|
 M.-A. Bona, M. Castellano, L. Plaza, and A. Fernandez Determination of Heavy Metals in Human Liver Human and Experimental Toxicology, January 1, 1992; 11(5): 311 - 313. [Abstract] [PDF]
|
|
|
|
 |
|
 J. R. Roeback Jr., K. M. Hla, L. E. Chambless, and R. H. Fletcher Effects of Chromium Supplementation on Serum High-Density Lipoprotein Cholesterol Levels in Men Taking Beta-Blockers: A Randomized, Controlled Trial Ann Intern Med, December 15, 1991; 115(12): 917 - 924. [Abstract] [PDF]
|
|
|
|
|
|
L. Howard, L. Heaphey, C. R. Fleming, L. Lininger, and E. Steiger Four Years of North American Registry Home Parenteral Nutrition Outcome Data and Their Implications for Patient Management JPEN J Parenter Enteral Nutr, July 1, 1991; 15(4): 384 - 393. [Abstract] [PDF]
|
|
|
|
|
|
Y. Ito, N. W. Alcock, and M. E. Shils Chromium Content of Total Parenteral Nutrition Solutions JPEN J Parenter Enteral Nutr, November 1, 1990; 14(6): 610 - 614. [Abstract] [PDF]
|
|
|
|
|
|
M. Shike Trace Elements in Parenteral Nutrition Nutr Clin Pract, December 1, 1987; 2(6): 228 - 229. [PDF]
|
|
|
|
|
|
I. A. Melki, N. M. Bulus, and N. N. Abumrad Invited Review: Trace Elements in Nutrition Nutr Clin Pract, December 1, 1987; 2(6): 230 - 240. [PDF]
|
|
|
|
|
|
C.L. Kien, C. Veillon, K.Y. Patterson, and P.M. Farrell Mild Peripheral Neuropathy but Biochemical Chromium Sufficiency during 16 Months of "Chromium-Free" Total Parenteral Nutrition JPEN J Parenter Enteral Nutr, November 1, 1986; 10(6): 662 - 664. [Abstract] [PDF]
|
|
|
|
|
|
L. Howard, L. L. Heaphey, and M. Timchalk A Review of the Current National Status of Home Parenteral and Enteral Nutrition from the Provider and Consumer Perspective JPEN J Parenter Enteral Nutr, July 1, 1986; 10(4): 416 - 424. [Abstract] [PDF]
|
|
|
|
 |
|
 R. W. Thatcher and M. L. Lester Nutrition, Environmental Toxins and Computerized EEG: A Mini-Max Approach to Learning Disabilities J Learn Disabil, May 1, 1985; 18(5): 287 - 297. [Abstract] [PDF]
|
|
|
|
 |
|
 W. E. May Nutritional Sensory Neuronopathy: An Emerging New Syndrome Arch Neurol, May 1, 1984; 41(5): 559 - 560. [Abstract] [PDF]
|
|
|
|
|
|
B. A. Bivins, R. M. Bell, R. P. Rapp, and W. O. Griffen JR. Linoleic Acid Versus Linolenic Acid: What Is Essential? JPEN J Parenter Enteral Nutr, September 1, 1983; 7(5): 473 - 478. [PDF]
|
|
|
|
 |
|
 W Mertz The essential trace elements Science, September 18, 1981; 213(4514): 1332 - 1338. [Abstract] [PDF]
|
|
|
|
|
|
C. J. Mcclain Trace Metal Abnormalities in Adults During Hyperalimentation JPEN J Parenter Enteral Nutr, September 1, 1981; 5(5): 424 - 429. [Abstract] [PDF]
|
|
|
|
|
|
G. D. Phillips and V. P. Garnys Trace Element Balance in Adults Receiving Parenteral Nutrition: Preliminary Data JPEN J Parenter Enteral Nutr, January 1, 1981; 5(1): 11 - 14. [Abstract] [PDF]
|
|
|
|
|
|
L. HOWARD, R. CHU, S. FEMAN, H. MINTZ, L. OVESEN, and B. WOLF Vitamin A Deficiency from Long-Term Parenteral Nutrition Ann Intern Med, October 1, 1980; 93(4): 576 - 577. [Abstract] [PDF]
|
|
|
|
 |
|
 J. C. L. Shaw Trace Elements in the Fetus and Young Infant: II. Copper, Manganese, Selenium, and Chromium Arch Pediatr Adolesc Med, January 1, 1980; 134(1): 74 - 81. [Abstract] [PDF]
|
|
|
|
|
|
A. M. van Rij, J. M. Mc Kenzie, M. F. Robinson, and C. D. Thomson Selenium and Total Parenteral Nutrition JPEN J Parenter Enteral Nutr, July 1, 1979; 3(4): 235 - 239. [Abstract] [PDF]
|
|
|
|
|
|
Guidelines for Essential Trace Element Preparations for Parenteral Use A Statement by the Nutrition Advisory Group JPEN J Parenter Enteral Nutr, July 1, 1979; 3(4): 263 - 267. [PDF]
|
|
|
|
 |
|
 AMA Department of Foods and Nutrition Guidelines for Essential Trace Element Preparations for Parenteral Use: A Statement by an Expert Panel JAMA, May 11, 1979; 241(19): 2051 - 2054. [Abstract] [PDF]
|
|
|
|
|
|
H. Freund, S. Atamian, and J. E. Fischer Chromium Deficiency During Total Parenteral Nutrition JAMA, February 2, 1979; 241(5): 496 - 498. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
