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American Journal of Clinical Nutrition, Vol 30, 592-598, Copyright © 1977 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Weight fluctuations after immunization in a rural preschool child community

AA Kielmann

After inoculations with diphtheria, pertussis, tetanus (DPT), smallpox Bacillus Calmette-Guerin (BCG), polio, and DPT + polio vaccine preparations, weight-for-age fluctuations were monitored in over 470 rural preschool children and compared to those in nonvaccinated control children matched for age, weight-for-age, season and year of immunization, and village affiliation. It was found that children immunized with live agents (BCG, smallpox, polio, DPT + polio) who also were below 6 months of age suffered statistically significant reductions in their weight-for-age compared to matched nonimmunized controls. Children inoculated with polio or smallpox who also were below 80% of the Harvard weight-for-age median experienced a larger decrease in their nutritional levels than those above, with correction for age distribution. It is suggested that in the developing world immunizations with live agents to children below 6 months of age should be given only if the infectious illness in which immunization is provided poses a real threat to health, or if vaccination coverage of children above 6 months of age would subsequently be difficult to achieve.


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L.-a. Pirofski and A. Casadevall
Use of Licensed Vaccines for Active Immunization of the Immunocompromised Host
Clin. Microbiol. Rev., January 1, 1998; 11(1): 1 - 26.
[Abstract] [Full Text] [PDF]


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