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American Journal of Clinical Nutrition, Vol 30, 1512-1513, Copyright © 1977 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Specific metabolic effects imposed by Streptococcus pneumoniae upon the response to femoral fracture in the rat

MV Kaminski Jr, HA Neufeld, RW Wannemacher Jr, ML Armstrong and L Strobel

The possible potentiation of an infection upon the metabolic consequences of trauma was tested in rats using a 2 X 2 block design which included control, femoral fracture, pneumococcal infection, and fracture plus infection groups. Infection introduced unique metabolic effects different from those of starvation, femoral fracture, or both together. Infection-induced effects included an accelerated conversion of 14C-alanine to glucose, higher serum haptoglobin, alpha2- macrofetoprotein, copper, and ceruloplasmin values, and lower serum iron, zinc, and transferrin concentrations. The first three of these infection-induced effects were diminished in rats with a femoral fracture. No measured effect of infection was increased in traumatized rats.


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Copyright © 1977 by The American Society for Nutrition