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American Journal of Clinical Nutrition, Vol 31, 1322-1327, Copyright © 1978 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Studies on 3-methylhistidine metabolism in children with protein-energy malnutrition

VS Nagabhushan and BS Narasinga Rao

Twenty-four hour urinary excretion of 3-methylhistidine (3-MeHis) was determined in children suffering from severe and moderate degrees of protein-energy malnutrition before and after treatment. Excretion of 3- MeHis was decreased both in children with severe protein-energy malnutrition and during undernutrition and increased considerably after treatment. The results suggest that there is a quantitative as well as a qualitative change in 3-MeHis metabolism in protein-energy malnutrition. A sensitive index for studying muscle protein metabolism is not available so far. Studies reported herein seem to suggest that 3- MeHis may fulfill such a requirement.




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Copyright © 1978 by The American Society for Nutrition