AJCN EB Program 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kopple, J. D.
Right arrow Articles by Swendseid, M. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kopple, J. D.
Right arrow Articles by Swendseid, M. E.
Agricola
Right arrow Articles by Kopple, J. D.
Right arrow Articles by Swendseid, M. E.

American Journal of Clinical Nutrition, Vol 31, 1532-1540, Copyright © 1978 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Amino acid and protein metabolism in renal failure

JD Kopple, M Jones, S Fukuda and ME Swendseid

There are many cAUSES OF ALTERED AMINO ACID AND PROTEIN METABOLISM IN UREMIA WHICH MAY Lead to impaired growth, wasting, malnutrition, and other aspects of the uremic syndrome. These causes have complex interrelationships that are not well understood. The factors include altered nutrition due to poor intake, losses of nutrients during dialysis, and abnormal metabolism of many nutrients. Uremic toxins, superimposed catabolic illnesses, elevated or reduced serum hormone levels, reduced capacity of the kidney to synthesize certain amino acids and to degrade other amino acids, peptides, and small proteins, and decreased excretion of certain amino acids and peptides may also contribute to altered amino acid and protein metabolism. The response of certain plasma amino acids to protein restriction appears to differ in uremic patients as compared to normal subjects. Increased plasma levels of many products of amino acids and proteins in renal failure are due primarily to decreased urinary clearance by the kidney. However, for some metabolites, increased synthesis or decreased degradation may also contribute to elevated levels. These latter compounds include guanidinosuccinic acid, methylguanidine, certain middle molecules, and in some patients, phenylpyruvic acid.


This article has been cited by other articles:


Home page
 J. Am. Soc. Nephrol.Home page
A. N. FRIEDMAN, A. G. BOSTOM, J. SELHUB, A. S. LEVEY, and I. H. ROSENBERG
The Kidney and Homocysteine Metabolism
J. Am. Soc. Nephrol., October 1, 2001; 12(10): 2181 - 2189.
[Abstract] [Full Text] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
M. Wolfson and J. D. Kopple
The Effect of Vitamin B6 Deficiency on Food Intake, Growth, and Renal Function in Chronically Azotemic Rats
JPEN J Parenter Enteral Nutr, July 1, 1987; 11(4): 398 - 402.
[Abstract] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
J. Takala
Total Plasma Clearance of Intravenous Essential Amino Acids: Evidence of Abnormal Metabolism of Amino Acids in Chronic Renal Failure
JPEN J Parenter Enteral Nutr, March 1, 1983; 7(2): 146 - 150.
[Abstract] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
J. M. Mirtallo, P. J. Schneider, K. Mavko, R. L. Ruberg, and P. J. Fabri
A Comparison of Essential and General Amino Acid Infusions in the Nutritional Support of Patients with Compromised Renal Function
JPEN J Parenter Enteral Nutr, March 1, 1982; 6(2): 109 - 113.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1978 by The American Society for Nutrition