| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
American Journal of Clinical Nutrition, Vol 31, 1587-1593, Copyright © 1978 by The American Society for Clinical Nutrition, Inc
ORIGINAL RESEARCH COMMUNICATIONS |
O Wrong
All three of the major human nitrogenous waste products--urea,, creatinine, and uric acid--are significantly degraded by intestinal bacteria. The breakdown products of creatinine and uric acid are not fully known, but metabolites of these complex heterocyclic nitrogen compounds may well turn out to play a role in uremic toxicity. Urea degradation is almost certainly by way of ammonia, but the exact site of urea hydrolysis in the alimentary tract is not known, and it is uncertain whether urea is the major source of intestinal ammonia. Ammonia is absorbed from the colon predominantly in unionized form, and the bicarbonate ion secreted by the colonic mucosa plays an important role in facilitating this absorption.
This article has been cited by other articles:
|
|
 |
|
  R. T. Worrell, L. Merk, and J. B. Matthews Ammonium transport in the colonic crypt cell line, T84: role for Rhesus glycoproteins and NKCC1 Am J Physiol Gastrointest Liver Physiol, February 1, 2008; 294(2): G429 - G440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Abdoun, F. Stumpff, K. Wolf, and H. Martens Modulation of electroneutral Na transport in sheep rumen epithelium by luminal ammonia Am J Physiol Gastrointest Liver Physiol, September 1, 2005; 289(3): G508 - G520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wolin Fermentation in the rumen and human large intestine Science, September 25, 1981; 213(4515): 1463 - 1468. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
