AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reiser, S.
Right arrow Articles by Prather, E. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reiser, S.
Right arrow Articles by Prather, E. S.
Agricola
Right arrow Articles by Reiser, S.
Right arrow Articles by Prather, E. S.

American Journal of Clinical Nutrition, Vol 32, 2206-2216, Copyright © 1979 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Isocaloric exchange of dietary starch and sucrose in humans. II. Effect on fasting blood insulin, glucose, and glucagon and on insulin and glucose response to a sucrose load

S Reiser, HB Handler, LB Gardner, JG Hallfrisch, OE Michaelis 4th and ES Prather

Ten men and nine women ages 35 to 55 consumed two diets for 6 weeks each in a cross-over design. The diets were composed of identical natural foods and 30% of the calories as either sucrose or wheat starch. Carbohydrate, fat, and protein supplied 43, 42, and 15% of the calories, respectively. Of the calories 10% was eaten at breakfast (7:00 to 8:30 AM) and 90% at dinner (4:30 to 6:30 PM). Inital body weights were essentially maintained. Fasting serum insulin and glucose levels were significantly higher with the sucrose than with the starch diet. The insulin response and the insulin:glucose ratios after a sucrose load (2 g/kg body weight) were greater after the subjects consumed the sucrose diet. Sucrose feeding produced increases in fasting serum insulin, the insulin:glucose ratio and the insulin response to a sucrose load that were of greater magnitude in a subgroup of nine subjects classified as potentially carbohydrate-sensitive than in normal subjects. Glucose response to a sucrose load and fasting serum glucagon did not differ significantly with diet. Fasting insulin and glucose showed significant increases as a function of time on diet. These results indicate that sucrose feeding produces undersirable changes in several of the parameters associated with glucose tolerance.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
D. Cao, H. Lu, T. L. Lewis, and L. Li
Intake of Sucrose-sweetened Water Induces Insulin Resistance and Exacerbates Memory Deficits and Amyloidosis in a Transgenic Mouse Model of Alzheimer Disease
J. Biol. Chem., December 14, 2007; 282(50): 36275 - 36282.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. Daly
Sugars, insulin sensitivity, and the postprandial state
Am. J. Clinical Nutrition, October 1, 2003; 78(4): 865S - 872.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. J. Berger and R. J. Barnard
Effect of diet on fat cell size and hormone-sensitive lipase activity
J Appl Physiol, July 1, 1999; 87(1): 227 - 232.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
M. Fields
Nutritional Factors Adversely Influencing the Glucose/Insulin System
J. Am. Coll. Nutr., August 1, 1998; 17(4): 317 - 321.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
H. G. Preuss, M. Zein, P. MacArthy, D. Dipette, S. Sabnis, and J. Knapka
Sugar-Induced Blood Pressure Elevations Over the Lifespan of Three Substrains of Wistar Rats
J. Am. Coll. Nutr., February 1, 1998; 17(1): 36 - 37.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1979 by The American Society for Nutrition