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American Journal of Clinical Nutrition, Vol 32, 2233-2236, Copyright © 1979 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Penicillin pharmacokinetics in kwashiorkor

N Buchanan, R Robinson, HJ Koornhof and C Eyberg

Intravenous penicillin kinetics have been studied in eight children with kwashiorkor on admission to hospital and when rehabilitated. A 75% increase in penicillin clearance was observed with recovery, associated with a fall in half-life; this was probably due to an improvement of both renal plasma flow and tubular function. The present observations and those of other authors working in this area are discussed and an approach to drug dosage of renally excreted drugs in kwashiorkor has been proposed.




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Copyright © 1979 by The American Society for Nutrition