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American Journal of Clinical Nutrition, Vol 32, 2265-2268, Copyright © 1979 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Leukocyte hexose monophosphate shunt activity during phagocytosis in vitamin B12 and folic acid deficiencies

MR Hamrell, P Hochstein and R Carmel

Little information exists about leukocytic function in megaloblastic anemia. A report of abnormal hexose monophosphate shunt and phagocytic activity only in vitamin B12 deficiency and not in folate deficiency prompted us to examine latex-stimulated hexose monophosphate shunt activity in the two conditions. Only two of our five patients with pernicious anemia demonstrated defective activation, while one of the two folate-deficient patients also had this defect. These findings clearly indicate that hexose monophosphate shunt activity is neither consistently impaired in vitamin B12 deficiency nor consistently unaffected in folate deficiency.




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Copyright © 1979 by The American Society for Nutrition