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American Journal of Clinical Nutrition, Vol 32, 1260-1266, Copyright © 1979 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

I. Depressed immunological function in zinc-deprived rats as measured by mitogen response of spleen, thymus, and peripheral blood

RL Gross, N Osdin, L Fong and PM Newberne

The in vitro responses of splenic, thymic, and peripheral blood lymphocytes to two T-cell mitogens (phytohemagglutinin and concanavalin A) and one B-cell mitogen (pokeweed mitogen) were investigated in zinc- deprived and pair-fed control rats. The responses to phytohemagglutinin of splenic, thymic, and peripheral blood lymphocytes from zinc-deprived animals were depressed by at least 50% in comparison with those of controls, and the difference between the two groups was significant for each tissue (P = 0.05). The responses to concanavalin A of splenic and peripheral blood lymphocytes were suppressed in zinc-deprived animals, and splenic and thymic responses to pokeweed mitogen were depressed by about 50% in comparison with those of controls; these results were significant at the P = 0.05 level. This study is the first to evaluate the effects of diet-induced zinc deprivation on lymphocyte transformation and immune function in rats.




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Copyright © 1979 by The American Society for Nutrition