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American Journal of Clinical Nutrition, Vol 32, 1267-1271, Copyright © 1979 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

II. In vitro restoration by levamisole of mitogen responsiveness in zinc-deprived rats

RL Gross, N Osdin, L Fong and PM Newberne

The effect of levamisole on the in vitro responses of splenic and peripheral blood lymphocytes to phytohemagglutinin were investigated in zinc-deprived and pair-fed control rats. The in vitro response of lymphocytes from zinc-deprived rats was markedly impaired in comparison with that of controls. The addition of levamisole to cultures of zinc- deprived splenic lymphocytes significantly improved their response to phytohemagglutinin by 54%. The addition of levamisole to cultures of zinc-deprived peripheral blood lymphocytes significantly improved their response by 116.2%. The addition of levamisole to control lymphocyte culture had no effect. This study may be the first to evaluate the beneficial effect of an immunomodulating agent on immune function in a nutritionally deprived host.


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J. I. ALLEN, N. E. KAY, and C. J. McCLAIN
Severe Zinc Deficiency in Humans: Association with a Reversible T-Lymphocyte Dysfunction
Ann Intern Med, August 1, 1981; 95(2): 154 - 157.
[Abstract] [PDF]


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Copyright © 1979 by The American Society for Nutrition