AJCN Cancer Health Disparities Conference
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sullivan, J. F.
Right arrow Articles by Burch, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sullivan, J. F.
Right arrow Articles by Burch, R. E.
Agricola
Right arrow Articles by Sullivan, J. F.
Right arrow Articles by Burch, R. E.

American Journal of Clinical Nutrition, Vol 33, 51-56, Copyright © 1980 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Enhanced lipid peroxidation in liver microsomes of zinc-deficient rats

JF Sullivan, MM Jetton, HK Hahn and RE Burch

The clinical association of decreased serum and hepatic zinc in patients with cirrhosis of the liver presumably arising from excess ethanol ingestion prompted a study of the activities of zinc and alcohol in experimental animals. The purpose of this study was to determine the effect of zinc deficiency upon lipid peroxidation in the liver. The effect of ethanol and zinc deficiency on lipid peroxidation was also evaluated. Rats were used in the experimental design, one group received a control diet, and one was maintained on a zinc- deficient diet. One-half of each group also received 3.85 g ethanol per kilogram body weight daily. Lipid peroxidation in vivo was determined by estimation of diene conjugation of microsomal lipids. The in vitro lipid peroxidation potential was measured by the generation of malonic dialdehyde by enzymatic as well as nonenzymatic reactions. Analysis of this data indicated that increased hepatic microsomal lipid peroxidation was associated with zinc deficiency whether using in vivo or in vitro indices of measurement. Review of the data from individual animals indicated that the lowest levels of serum zinc were associated with increased hepatic content of phospholipids. The degree of lipid peroxidation in the zinc deficient animals was not increased by ingestion of alcohol.


This article has been cited by other articles:


Home page
 IOVSHome page
K.-N. Ha, Y. Chen, J. Cai, and P. Sternberg Jr
Increased Glutathione Synthesis through an ARE-Nrf2-Dependent Pathway by Zinc in the RPE: Implication for Protection against Oxidative Stress.
Invest. Ophthalmol. Vis. Sci., June 1, 2006; 47(6): 2709 - 2715.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. G. Mackenzie, M. P. Zago, C. L. Keen, and P. I. Oteiza
Low Intracellular Zinc Impairs the Translocation of Activated NF-kappa B to the Nuclei in Human Neuroblastoma IMR-32 Cells
J. Biol. Chem., September 6, 2002; 277(37): 34610 - 34617.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
P. I. Oteiza, M. S. Clegg, and C. L. Keen
Short-Term Zinc Deficiency Affects Nuclear Factor-{{kappa}}B Nuclear Binding Activity in Rat Testes
J. Nutr., January 1, 2001; 131(1): 21 - 26.
[Abstract] [Full Text]

Home page
 J. Nutr.Home page
S. R. Powell
The Antioxidant Properties of Zinc
J. Nutr., May 1, 2000; 130(5): 1447S - 1454.
[Abstract] [Full Text]

Home page
 J. Nutr.Home page
E.-S. Kim, S. K. Noh, and S. I. Koo
Marginal Zinc Deficiency Lowers the Lymphatic Absorption of alpha -Tocopherol in Rats
J. Nutr., February 1, 1998; 128(2): 265 - 270.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1980 by The American Society for Nutrition