AJCN Tufts Nutrition Symposium, Boston Sept 24-26
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American Journal of Clinical Nutrition, Vol 33, 2192-2193, Copyright © 1980 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Orotic acid content of infant formulas

RP Durschlag and JL Robinson

The orotic acid content of four commercially available infant formulas has been examined. Enfamil contains 118 microgram orotic acid per milliliter as fed, Similac 98, SMA 27, and Isomil less than 1 microgram/ml. As expressed relative to total solids, these formulas contain less than 0.1% orotic acid. Since consumption of 1% orotic acid does not lead to a fatty liver in any species examined other than the rat and 0.1% orotic acid fails to induce statistically significant hepatic changes in the rat, it is suggested that orotic acid at the level found in these formulas is not likely to pose a health hazard to the infants consuming them.


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