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American Journal of Clinical Nutrition, Vol 33, 2281-2286, Copyright © 1980 by The American Society for Clinical Nutrition, Inc


ORIGINAL RESEARCH COMMUNICATIONS

Effectiveness of cimetidine as an adjunct to supplemental pancreatic enzymes in patients with cystic fibrosis

VS Hubbard, GD Dunn and LA Lester

The effectiveness and safety of the use of cimetidine as an adjunct to pancreatic enzymes was evaluated in eight patients with cystic fibrosis having pancreatic insufficiency. Cimetidine (300 mg, three times a day) was given for a 6-week period during which the patients demonstrated a significant weight gain (P < 0.05) and reduction of steatorrhea (P < 0.01). Data suggesting an early correction of the abnormal fatty acid composition of plasma lipids were observed. No side effects were apparent during the clinical trial. These results demonstrate the beneficial effects of the use of cimetidine in patients with cystic fibrosis and indicate the need for long-term clinical trials.


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Journal of Pharmacy PracticeHome page
J. H. Tran and K. M. Brennan
Management of the Child With Cystic Fibrosis
Journal of Pharmacy Practice, February 1, 1996; 9(1): 75 - 90.
[Abstract] [PDF]




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Copyright © 1980 by The American Society for Nutrition