American Journal of Clinical Nutrition, Vol 33, 273-278, Copyright © 1980 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Impaired cellular insulin binding and insulin sensitivity induced by high-fructose feeding in normal subjects

H Beck-Nielsen, O Pedersen and HO Lindskov

We have studied whether the sucrose-induced reduction of insulin sensitivity and cellular insulin binding in normal man is related to the fructose or the glucose moiety. Seven young healthy subjects were fed their usual diets plus 1000 kcal extra glucose per day and eight young healthy subjects were fed their usual diets with addition of 1000 kcal extra fructose per day. The dietary regimens continued for 1 week. Before change of diet there were no statistically significant differences between body weight and fasting plasma concentrations of glucose, insulin, and ketone bodies in the two groups studied. High- glucose feeding caused no significant changes in insulin binding or insulin sensitivity whereas high-fructose feeding was accompanied by a significant reduction both of insulin binding (P less than 0.05) and insulin sensitivity (P less than 0.05). The changes in insulin binding and insulin sensitivity correlated linearly (r = 0.52, P less than 0.01). We conclude that fructose seems to be responsible for the impaired insulin binding and insulin sensitivity induced by sucrose.

This article has been cited by other articles:

				G. Livesey and R. Taylor Fructose consumption and consequences for glycation, plasma triacylglycerol, and body weight: meta-analyses and meta-regression models of intervention studies Am. J. Clinical Nutrition, November 1, 2008; 88(5): 1419 - 1437. [Abstract] [Full Text] [PDF]

				O. Glushakova, T. Kosugi, C. Roncal, W. Mu, M. Heinig, P. Cirillo, L. G. Sanchez-Lozada, R. J. Johnson, and T. Nakagawa Fructose Induces the Inflammatory Molecule ICAM-1 in Endothelial Cells J. Am. Soc. Nephrol., September 1, 2008; 19(9): 1712 - 1720. [Abstract] [Full Text] [PDF]

				M. S Segal, L. G Sanchez-Lozada, and R. J Johnson Reply to RJ Hine and JS White Am. J. Clinical Nutrition, April 1, 2008; 87(4): 1063 - 1064. [Full Text] [PDF]

				H. K Choi and G. Curhan Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study BMJ, February 9, 2008; 336(7639): 309 - 312. [Abstract] [Full Text] [PDF]

				S. Reungjui, C. A. Roncal, W. Mu, T. R. Srinivas, D. Sirivongs, R. J. Johnson, and T. Nakagawa Thiazide Diuretics Exacerbate Fructose-Induced Metabolic Syndrome J. Am. Soc. Nephrol., October 1, 2007; 18(10): 2724 - 2731. [Abstract] [Full Text] [PDF]

				J. Montonen, R. Jarvinen, P. Knekt, M. Heliovaara, and A. Reunanen Consumption of Sweetened Beverages and Intakes of Fructose and Glucose Predict Type 2 Diabetes Occurrence J. Nutr., June 1, 2007; 137(6): 1447 - 1454. [Abstract] [Full Text] [PDF]

				T. Wu, E. Giovannucci, T. Pischon, S. E Hankinson, J. Ma, N. Rifai, and E. B Rimm Fructose, glycemic load, and quantity and quality of carbohydrate in relation to plasma C-peptide concentrations in US women Am. J. Clinical Nutrition, October 1, 2004; 80(4): 1043 - 1049. [Abstract] [Full Text] [PDF]

				M. Daly Sugars, insulin sensitivity, and the postprandial state Am. J. Clinical Nutrition, October 1, 2003; 78(4): 865S - 872. [Abstract] [Full Text] [PDF]

				S. S Elliott, N. L Keim, J. S Stern, K. Teff, and P. J Havel Fructose, weight gain, and the insulin resistance syndrome Am. J. Clinical Nutrition, November 1, 2002; 76(5): 911 - 922. [Abstract] [Full Text] [PDF]

				M. C. Moore, S. N. Davis, S. L. Mann, and A. D. Cherrington Acute Fructose Administration Improves Oral Glucose Tolerance in Adults With Type 2 Diabetes Diabetes Care, November 1, 2001; 24(11): 1882 - 1887. [Abstract] [Full Text] [PDF]