AJCN Tufts Nutrition Symposium, Boston Sept 24-26
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American Journal of Clinical Nutrition, Vol 33, 881-886, Copyright © 1980 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

A simple method for measuring zinc absorption in man using a short- lived isotope (69mZn)

M Molokhia, G Sturniolo, R Shields and LA Turnberg

Using a short-lived isotope of zinc (69mZn) with a half-life of 13.9 hr, we have developed a simple test of zinc absorption. After an oral dose of isotope (50 muCi) with 2 mg of elemental zinc a plasma appearance curve was constructed from radioactivity determined in blood samples taken sequentially over 8 hr. Two week later an iv dose of isotope (25 muCi) was administered and a plasma disappearance curve was constructed. Absorption was calculated by computer analysis of appearance and disappearance curves using a deconvolution programme. Mean absorption in five normal subjects was 61% (range 41 to 79%). In three subjects given food with, or 1 hr before the isotope, absorption was delayed and reduced to less than 20% of the oral dose at 8 hr. This test of zinc absorption is simple to perform and, because the isotope has a short half-life, has the advantage of subjecting patients to only limited radiation.


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N. M Lowe, L. R Woodhouse, J. S Matel, and J. C King
Comparison of estimates of zinc absorption in humans by using 4 stable isotopic tracer methods and compartmental analysis1
Am. J. Clinical Nutrition, February 1, 2000; 71(2): 523 - 529.
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