AJCN EB Program 2010 Early Registration
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lloyd-Still, J. D.
Right arrow Articles by Holman, R. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lloyd-Still, J. D.
Right arrow Articles by Holman, R. T.
Agricola
Right arrow Articles by Lloyd-Still, J. D.
Right arrow Articles by Holman, R. T.

American Journal of Clinical Nutrition, Vol 34, 1-7, Copyright © 1981 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Essential fatty acid status in cystic fibrosis and the effects of safflower oil supplementation

JD Lloyd-Still, SB Johnson and RT Holman

The fatty acid compositions of serum phospholipids, cholesteryl esters, triglycerides, and free fatty acids were determined on a group of cystic fibrosis patients. These were compared with similar data from random hospitalized patients of the same age groups of both sexes. Fatty acid patterns in all lipid classes were skewed in the direction of essential fatty acid deficiency, but the differences were most dramatic in phospholipids. Many calculated parameters useful as indices of essential fatty acid status indicated that essential fatty acid deficiency exists in cystic fibrosis. Treatment of 11 cystic fibrosis patients with safflower oil (1 g/kg/day) failed to correct the aberrations in fatty acid pattern. The biochemical data suggest that there may be an impairment in conversion of linoleate to arachidonate as well as an impairment of absorption.


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
L. Iuliano, R. Monticolo, G. Straface, S. Zullo, F. Galli, M. Boaz, and S. Quattrucci
Association of cholesterol oxidation and abnormalities in fatty acid metabolism in cystic fibrosis
Am. J. Clinical Nutrition, September 1, 2009; 90(3): 477 - 484.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Pierre, M.-O. Husson, R. L. Berre, J.-L. Desseyn, C. Galabert, L. Beghin, C. Beermann, A. Dagenais, Y. Berthiaume, B. Cardinaud, et al.
Omega-3 polyunsaturated fatty acids improve host response in chronic Pseudomonas aeruginosa lung infection in mice
Am J Physiol Lung Cell Mol Physiol, June 1, 2007; 292(6): L1422 - L1431.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
I. Batal, M.-B. Ericsoussi, J. E. Cluette-Brown, B. P. O'Sullivan, S. D. Freedman, J. E. Savaille, and M. Laposata
Potential Utility of Plasma Fatty Acid Analysis in the Diagnosis of Cystic Fibrosis
Clin. Chem., January 1, 2007; 53(1): 78 - 84.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
A. Werner, M. E. J. Bongers, M. J. Bijvelds, H. R. de Jonge, and H. J. Verkade
No indications for altered essential fatty acid metabolism in two murine models for cystic fibrosis
J. Lipid Res., December 1, 2004; 45(12): 2277 - 2286.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
S. D. Freedman, P. G. Blanco, M. M. Zaman, J. C. Shea, M. Ollero, I. K. Hopper, D. A. Weed, A. Gelrud, M. M. Regan, M. Laposata, et al.
Association of Cystic Fibrosis with Abnormalities in Fatty Acid Metabolism
N. Engl. J. Med., February 5, 2004; 350(6): 560 - 569.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
F. N. Bhura-Bandali, M. Suh, S. F. P. Man, and M. T. Clandinin
The {{Delta}}F508 Mutation in the Cystic Fibrosis Transmembrane Conductance Regulator Alters Control of Essential Fatty Acid Utilization in Epithelial Cells
J. Nutr., December 1, 2000; 130(12): 2870 - 2875.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. D. Freedman, M. H. Katz, E. M. Parker, M. Laposata, M. Y. Urman, and J. G. Alvarez
A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr-/- mice
PNAS, November 23, 1999; 96(24): 13995 - 14000.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
G. L. Darmstadt, C. P. Schmidt, D. S. Wechsler, W. W. Tunnessen, and B. J. Rosenstein
Dermatitis as a Presenting Sign of Cystic Fibrosis
Arch Dermatol, October 1, 1992; 128(10): 1358 - 1364.
[Abstract] [PDF]

Home page
 CLIN PEDIATRHome page
E.A. Mitchell, M. G. Aman, S. H. Turbott, and M. Manku
Clinical Characteristics and Serum Essential Fatty Acid Levels in Hyperactive Children
Clinical Pediatrics, August 1, 1987; 26(8): 406 - 411.
[Abstract] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
L. A. Lester, R. M. Rothberg, G. Dawson, A. L. Lopez, and Z. Corpuz
Supplemental Parenteral Nutrition in Cystic Fibrosis
JPEN J Parenter Enteral Nutr, May 1, 1986; 10(3): 289 - 295.
[Abstract] [PDF]

Home page
 International Journal of ToxicologyHome page
6 Final Report on the Safety Assessment of Safflower Oil
International Journal of Toxicology, September 1, 1985; 4(5): 171 - 197.
[Abstract] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
C. Landon, J. A. Kerner, R. Castillo, L. Adams, R. Whalen, and N. J. Lewiston
Oral Correction of Essential Fatty Acid Deficiency in Cystic Fibrosis
JPEN J Parenter Enteral Nutr, November 1, 1981; 5(6): 501 - 504.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1981 by The American Society for Nutrition