AJCN Tufts Nutrition Symposium, Boston Sept 24-26
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Milne, D. B.
Right arrow Articles by Amos, W. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Milne, D. B.
Right arrow Articles by Amos, W. H., Jr
Agricola
Right arrow Articles by Milne, D. B.
Right arrow Articles by Amos, W. H.

American Journal of Clinical Nutrition, Vol 34, 2389-2393, Copyright © 1981 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Effect of ascorbic acid on copper and cholesterol in adult cynomolgus monkeys fed a diet marginal in copper

DB Milne, ST Omaye and WH Amos Jr

The effects of prolonged consumption of high levels of dietary ascorbic acid on copper metabolism and cholesterol in adult monkeys fed a diet low or marginal in copper were investigated. Small reductions in serum copper and in serum ceruloplasmin levels were observed when high levels of ascorbic acid were fed. During the period of copper depletion there was a gradual but significant (p less than 0.001) increase in serum cholesterol. The level of ascorbic acid supplementation had no effect during this phase. When copper was added back to the diet, serum cholesterol levels leveled off or declined in the monkeys receiving the low (1 mg/day/kg body weight) dose of ascorbic acid. Cholesterol levels continued to increase in the group receiving the higher ascorbic acid supplement (25 mg/day/kg body weight). These data suggest that high levels of ascorbic acid supplementation may make dietary copper relatively unavailable for regulating cholesterol metabolism.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1981 by The American Society for Nutrition