AJCN Tufts Nutrition Symposium, Boston & Online Sept 2009
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Powanda, M. C.
Right arrow Articles by Beisel, W. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Powanda, M. C.
Right arrow Articles by Beisel, W. R.
Agricola
Right arrow Articles by Powanda, M. C.
Right arrow Articles by Beisel, W. R.

American Journal of Clinical Nutrition, Vol 35, 762-768, Copyright © 1982 by The American Society for Clinical Nutrition, Inc

REVIEW ARTICLES

Hypothesis: leukocyte endogenous mediator/endogenous pyrogen/lymphocyte- activating factor modulates the development of nonspecific and specific immunity and affects nutritional status

MC Powanda and WR Beisel

We postulate that leukocyte endogenous mediator/endogenous pyrogen/lymphocyte-activating factor (LEM/EP/LAF) integrates the host's nonspecific and specific immune responses to infection by virtue of the panoply of physiological and metabolic activities it is capable of eliciting. The alterations in systemic metabolism modulated by LEM/EP/LAF, although apparently of value to the host in the defense against infection and the repair of tissue damage, result in negative nutrient balances. Severe infections, alone or in conjunction with injury, may result in malnutrition unless the patient is adequately nourished. Preexisting nutritional deficits can compromise host resistance to infection, in part by preventing production of LEM/EP/LAF. Additional studies of the sequelae of LEM/EP/LAF action and effects of nutrition on host resistance to infection appear warranted.


This article has been cited by other articles:


Home page
 J. Nutr.Home page
M. C. Powanda and W. R. Beisel
Metabolic Effects of Infection on Protein and Energy Status
J. Nutr., January 1, 2003; 133(1): 322S - 327.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
D. P. Kotler
Cachexia
Ann Intern Med, October 17, 2000; 133(8): 622 - 634.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
R. L. Gamelli
Nutritional Problems of the Acute and Chronic Burn Patient: Relevance to Epidermolysis Bullosa
Arch Dermatol, May 1, 1988; 124(5): 756 - 759.
[Abstract] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
H. Gilder
Parenteral Nourishment of Patients Undergoing Surgical or Traumatic Stress
JPEN J Parenter Enteral Nutr, January 1, 1986; 10(1): 88 - 99.
[Abstract] [PDF]

Home page
 JPEN J Parenter Enteral NutrHome page
J. L. Duncan, L. L. Moldawer, B. R. Bistrian, and G. L. Blackburn
In Vitro Leukocyte Endogenous Mediator Production Is Not Impaired following Surgical Stress in Moderately Malnourished Patients
JPEN J Parenter Enteral Nutr, March 1, 1984; 8(2): 174 - 177.
[Abstract] [PDF]

Home page
 Arch Intern MedHome page
B. Mizock
Septic Shock: A Metabolic Perspective
Arch Intern Med, March 1, 1984; 144(3): 579 - 585.
[Abstract] [PDF]

Home page
 Arch SurgHome page
S. Rosenblatt, G. H. A. Clowes Jr, B. C. George, E. Hirsch, and B. Lindberg
Exchange of Amino Acids by Muscle and Liver in Sepsis: Comparative Studies In Vivo and In Vitro
Arch Surg, February 1, 1983; 118(2): 167 - 175.
[Abstract] [PDF]

Home page
 ScienceHome page
A Flynn, J. Finke, and M. Hilfiker
Placental mononuclear phagocytes as a source of interleukin-1
Science, October 29, 1982; 218(4571): 475 - 477.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1982 by The American Society for Nutrition