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American Journal of Clinical Nutrition, Vol 35, 973-980, Copyright © 1982 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Reduced alternative complement pathway control protein levels in anorexia nervosa: response to parenteral alimentation

RJ Wyatt, M Farrell, PL Berry, J Forristal, MJ Maloney and CD West

Serum levels of 16 proteins, including 11 component and control proteins of the complement system were determined before and after nutritional repletion in five female patients with severe malnutrition secondary to anorexia nervosa. Before parenteral alimentation significantly decreased serum levels were found for IgG, IgM, transferrin, Clq, C2, C3, factor B, beta lH, C3b inactivator, properdin, and C4 binding protein. A significant increase in posttreatment serum levels compared with pretreatment levels were found for transferrin, C3, factor B, beta lH, and C3b inactivator. Of the proteins measured, the C3b amplification loop control and component proteins, beta lH, C3b inactivator, C3, and factor B rose to the normal range in response to therapy most rapidly. In the absence of an acute phase reaction, these proteins appear to be particularly good indices of malnutrition and its response to therapy.


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 Arch Pediatr Adolesc MedHome page
L. F. EICHENFIELD and R. B. JOHNSTON JR
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Arch Pediatr Adolesc Med, December 1, 1989; 143(12): 1392 - 1392.
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 Arch Pediatr Adolesc MedHome page
L. H. SIGAL and B. K. SNYDER
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Arch Pediatr Adolesc Med, December 1, 1989; 143(12): 1391 - 1392.
[Abstract] [PDF]

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Copyright © 1982 by The American Society for Nutrition