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American Journal of Clinical Nutrition, Vol 35, 993-996, Copyright © 1982 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

Hypercalcemia associated with parenteral amino acid and dextrose infusion

JE Gilligan, S Hagley, LI Worthley, J Moran, M Way, CA Pitcher, TF Hartley, AG Need, DW Thomas, PJ Phillips, WB Dollman and D Martin

A patient receiving parenteral nutrition with an amino acid dextrose solution developed hypercalcemia which seemed related to the rate of nutrient infusion. In a retrospective study of patients receiving parenteral nutrition over a 3-month period six of 72 (8%) developed hypercalcemia. After changes in infusion rate there were corresponding changes in the serum calcium concentration. There was a significant correlation between the serum calcium concentration and the average infusion rate over the preceding four days (p = 0.012). This was even more significant (p less than 0.005) when ionized calcium was calculated to diminish the effects of calcium binding by proteins.


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