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American Journal of Clinical Nutrition, Vol 36, 855-861, Copyright © 1982 by The American Society for Clinical Nutrition, Inc

ORIGINAL RESEARCH COMMUNICATIONS

The bioavailability for humans of bound niacin from wheat bran

EG Carter and KJ Carpenter

Ethanolic wheat bran extracts were dialyzed and dried on starch. One portion [bound niacin (BN)] was cooked in steam; another [alkali- treated bound niacin (ABN)] was made alkaline with calcium oxide and then cooked. The niacin in BN was bound to large molecules (gel filtration); in ABN it was free. Three subjects each consumed a standard daily diet containing approximately 20 mg niacin equivalents. Urine was collected throughout. From day 14, each received three doses in random order at 8-day intervals. The doses, each spread over 2 days, were of BN and ABN, containing 35 mg niacin and 24 mg pure nicotinic acid. The above base-line response in urinary metabolites (N1- methylnicotinamide + N1-methyl-2-pyridone-5-carboxamide) over the 6 days from the beginning of each dose was equivalent to 24% of ingested niacin after BN, 62% after ABN and 89% after nicotinic acid. The niacin in BN appeared mostly unavailable.


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A. H. Lichtenstein and R. M. Russell
Essential Nutrients: Food or Supplements?: Where Should the Emphasis Be?
JAMA, July 20, 2005; 294(3): 351 - 358.
[Abstract] [Full Text] [PDF]


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